A physiologically-based pharmacokinetic model for the antibiotic ertapenem

A physiologically-based pharmacokinetic model for the antibiotic ertapenem

Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections, which is part of a broader class of antibiotics called carbapenem. Unlike other carbapenems, ertapenem has a longer half-life and thus only has to be administered once a day. A physiologically-based pharmacokinetic (P...

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Bibliographic Details
Main Authors: Michele L. Joyner, Cammey C. Manning, Whitney Forbes, Michelle Maiden, Ariel N. Nikas
Format: Article
Language:English
Published: AIMS Press 2015-09-01
Series:Mathematical Biosciences and Engineering
Subjects:
ertapenem
physiologically based pharmacokinetic model (pbpk)
free concentration
ordinary differentialequations.
bound concentration
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2016.13.119
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https://www.aimspress.com/article/doi/10.3934/mbe.2016.13.119

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