Identification of immune-related diagnostic genes and immune cell infiltration in aseptic loosening of prostheses after total hip arthroplasty by integrated bioinformatics analysis and experimental confirmation

Identification of immune-related diagnostic genes and immune cell infiltration in aseptic loosening of prostheses after total hip arthroplasty by integrated bioinformatics analysis and experimental confirmation

BackgroundAseptic loosening (AL) of hip prostheses is one of the main reasons for revision total hip arthroplasty (rTHA). However, the transcriptomic characteristics of AL are scarcely understood. This study aimed to discover candidate biomarkers for the diagnosis of AL.Patients and methodsThe inter...

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Bibliographic Details
Main Authors: Yunke Liu, Xiaming Liang, Shuo Qiang, Yonghui Dong, Xin Zhao, Lichao Ma, Zhihua Yan, Songkai Yue, Yifan Huang, Jia Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Genetics
Subjects:
aseptic loosening
total hip arthroplasty
macrophages
bioinformatics
immune infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1597219/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1597219/full

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