Protective anti‐prion antibodies in human immunoglobulin repertoires

Protective anti‐prion antibodies in human immunoglobulin repertoires

Abstract Prion immunotherapy may hold great potential, but antibodies against certain PrP epitopes can be neurotoxic. Here, we identified > 6,000 PrP‐binding antibodies in a synthetic human Fab phage display library, 49 of which we characterized in detail. Antibodies directed against the flexible...

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Main Authors: Assunta Senatore, Karl Frontzek, Marc Emmenegger, Andra Chincisan, Marco Losa, Regina Reimann, Geraldine Horny, Jingjing Guo, Sylvie Fels, Silvia Sorce, Caihong Zhu, Nathalie George, Stefan Ewert, Thomas Pietzonka, Simone Hornemann, Adriano Aguzzi
Format: Article
Language:English
Published: Springer Nature 2020-08-01
Series:EMBO Molecular Medicine
Subjects:
anti‐PrP antibodies
human immunological repertoires
next‐generation sequencing
phage display
prion disease
Online Access:https://doi.org/10.15252/emmm.202012739
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https://doi.org/10.15252/emmm.202012739

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