Neurological outcomes with hypothermia versus normothermia in patients with moderate initial illness severity following resuscitation from out-of-hospital cardiac arrest: protocol for a multicentre randomised controlled trial (R-CAST OHCA)

Neurological outcomes with hypothermia versus normothermia in patients with moderate initial illness severity following resuscitation from out-of-hospital cardiac arrest: protocol for a multicentre randomised controlled trial (R-CAST OHCA)

Introduction Temperature control is a fundamental intervention for neuroprotection following resuscitation from cardiac arrest. However, evidence regarding the efficacy of hypothermia in post-cardiac arrest syndrome (PCAS) remains unclear. Retrospective studies suggest that the clinical effectivenes...

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Main Authors: Takeyuki Kiguchi, Taku Iwami, Yohei Okada, Tadashi Ishihara, Yusuke Ito, Yoshitaka Ogata, Takayuki Ogura, Tetsuya Yumoto, Hiromichi Narumiya, Hiroyuki Honda, Hisashi Dote, Hiromichi Naito, Takashi Yorifuji, Hiroki Maeyama, Atsunori Nakao, Hiroyuki Tanaka, Yuichi Okano, Hidetada Fukushima, Kei Nishiyama, YASUHIRO KURODA, Tetsuro Nikai, Taka-aki Nakada, Akihito Tampo, Mitsuaki Nishikimi, Ryosuke Ishida, Naofumi Bunya, Takayuki Otani, Masaaki Sakuraya, Kazuki Nishida, Shigeyuki Matsui, Tsuruta Ryosuke, Koichi Hayakawa, Toshihiro Sakurai, Shota Nakao, Ryuhei Igeta, Shoichiro Nohara, Junichi Maruyama, Midori Tsuchiya, Nao Tsukamoto, Tomoko Sato, Chikaaki Nakamichi, Tatsuya Miyakoshi, Satoshi Kikuchi, Futoshi Nagashima, Jun Sato
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/8/e101809.full
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