DSS1 is required for proper Integrator–PP2A function
Abstract Integrator–PP2A (INTAC) is a highly modular complex orchestrating the transition of paused RNA polymerase II into productive elongation or promoter-proximal premature termination, with its loss resulting in transcription dysregulation and genome instability. Here, we identify human DSS1—a f...
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| Main Authors: | Congling Xu, Qian-Xing Zhou, Hai Zheng, Aixia Song, Wen-Ying Zhao, Ting-Ting Xu, Yan Xiong, Yi-Jie Zhang, Zixuan Huang, Yanhui Xu, Jingdong Cheng, Fei Xavier Chen |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61257-4 |
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