Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition

Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition

Aberrant glycosylation, especially sialylation, on cell surface is often associated with cancer progression and immunosuppression. Over-sialylation of stage-specific embryonic antigen-4 (SSEA-4) to generate disialylGb5 (DSGb5) was reported to trigger Siglec-7 recognition and suppress NK-mediated tar...

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Main Authors: Kuo-Shiang Liao, Yixuan Zhou, Cinya Chung, Chih-Chuan Kung, Chien-Tai Ren, Chung-Yi Wu, Yi-Wei Lou, Po-Kai Chuang, Balázs Imre, Yves S. Y. Hsieh, Chi-Huey Wong
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
sialyl SSEA-4
programmable
chemoenzymatic synthesis
glycolyl sialic acid
immune checkpoint
Online Access:https://www.mdpi.com/1420-3049/30/11/2264
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