Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials
The clinical trial, a prospective study to evaluate the effect of interventions in humans under prespecified conditions, is a standard and integral part of modern medicine. Many adaptive and sequential approaches have been proposed for use in clinical trials to allow adaptations or modifications to...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Probability and Statistics |
| Online Access: | http://dx.doi.org/10.1155/2012/527351 |
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| _version_ | 1850177632933511168 |
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| author | Zhengjia Chen Yichuan Zhao Ye Cui Jeanne Kowalski |
| author_facet | Zhengjia Chen Yichuan Zhao Ye Cui Jeanne Kowalski |
| author_sort | Zhengjia Chen |
| collection | DOAJ |
| description | The clinical trial, a prospective study to evaluate the effect of interventions in humans under prespecified conditions, is a standard and integral part of modern medicine. Many adaptive and sequential approaches have been proposed for use in clinical trials to allow adaptations or modifications to aspects of a trial after its initiation without undermining the validity and integrity of the trial. The application of adaptive and sequential methods in clinical trials has significantly improved the flexibility, efficiency, therapeutic effect, and validity of trials. To further advance the performance of clinical trials and convey the progress of research on adaptive and sequential methods in clinical trial design, we review significant research that has explored novel adaptive and sequential approaches and their applications in Phase I, II, and III clinical trials and discuss future directions in this field of research. |
| format | Article |
| id | doaj-art-c3fade74e991497d9b874f3bf0587c23 |
| institution | OA Journals |
| issn | 1687-952X 1687-9538 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Probability and Statistics |
| spelling | doaj-art-c3fade74e991497d9b874f3bf0587c232025-08-20T02:18:56ZengWileyJournal of Probability and Statistics1687-952X1687-95382012-01-01201210.1155/2012/527351527351Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical TrialsZhengjia Chen0Yichuan Zhao1Ye Cui2Jeanne Kowalski3Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USADepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USADepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USADepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USAThe clinical trial, a prospective study to evaluate the effect of interventions in humans under prespecified conditions, is a standard and integral part of modern medicine. Many adaptive and sequential approaches have been proposed for use in clinical trials to allow adaptations or modifications to aspects of a trial after its initiation without undermining the validity and integrity of the trial. The application of adaptive and sequential methods in clinical trials has significantly improved the flexibility, efficiency, therapeutic effect, and validity of trials. To further advance the performance of clinical trials and convey the progress of research on adaptive and sequential methods in clinical trial design, we review significant research that has explored novel adaptive and sequential approaches and their applications in Phase I, II, and III clinical trials and discuss future directions in this field of research.http://dx.doi.org/10.1155/2012/527351 |
| spellingShingle | Zhengjia Chen Yichuan Zhao Ye Cui Jeanne Kowalski Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials Journal of Probability and Statistics |
| title | Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials |
| title_full | Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials |
| title_fullStr | Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials |
| title_full_unstemmed | Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials |
| title_short | Methodology and Application of Adaptive and Sequential Approaches in Contemporary Clinical Trials |
| title_sort | methodology and application of adaptive and sequential approaches in contemporary clinical trials |
| url | http://dx.doi.org/10.1155/2012/527351 |
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