Characterization and optimization of mnn11Δ-mediated enhancement in heterologous protein production in Kluyveromyces marxianus

Abstract Background N-glycosylation is a prevalent post-translational modification in eukaryotes, essential for regulating protein secretion. In Saccharomyces cerevisiae, glycosylation mutants have been shown to enhance the secretion of heterologous glycosylated proteins. However, whether these muta...

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Bibliographic Details
Main Authors: Shihao Zhou, Pingping Wu, Haiyan Ren, Jungang Zhou, Yao Yu, Hong Lu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Microbial Cell Factories
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Online Access:https://doi.org/10.1186/s12934-025-02676-2
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