A comprehensive welfare scoring system for graft versus host disease clinical assessment in humanised mouse models used for pharmaceutical research

A comprehensive welfare scoring system for graft versus host disease clinical assessment in humanised mouse models used for pharmaceutical research

Immuno-oncology drug discovery increasingly relies on humanised mouse models of cancer due to limitations of murine surrogate tools and differences between mouse and human immune systems. Graft-versus-Host Disease (GvHD) is a significant complication following xenogeneic transplantation of human imm...

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Main Authors: Alice Nowak, Rebecca Marlow, Kelli Ryan, Jean-Martin Lapointe, Daniel Sutton, Alan Sharpe, Lucy Crook, Jennifer A. Walker, Emma Little, John Peverill, Adam Holberry-Brown, Emma Wassell, Robbie McLaren-Jones, Chelsea Cavanagh, Alex Vlad Dobre, Tamara Baker, Matthew Clayton, Natasha A. Karp, Michiel Plugge, Aurélie A. Thomas, Simon J. Dovedi, Suzanne I. Sitnikova, Natalie Burrows
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
GvHD (graft-versus-host disease)
humanised animal model
immuno-oncology
3Rs (reduce replace refine)
oncology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617528/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617528/full

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