Dendritic cells activate pyroptosis and effector-triggered apoptosis to restrict Legionella infection

Dendritic cells activate pyroptosis and effector-triggered apoptosis to restrict Legionella infection

ABSTRACT The innate immune system relies on pattern recognition receptors (PRRs) to detect pathogen-associated molecular patterns (PAMPs) and guard proteins to monitor pathogen disruption of host cell processes. How different immune cell types engage PRRs and guard proteins to respond to infection i...

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Main Authors: Víctor R. Vázquez Marrero, Jessica Doerner, Kimberly A. Wodzanowski, Jenna Zhang, Allyson Lu, Frankie D. Boyer, Isabel Vargas, Suzana Hossain, Karly B. Kammann, Madison V. Dresler, Sunny Shin
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Legionella pneumophila
dendritic cells
pyroptosis
apoptosis
guard immunity
innate immunity
Online Access:https://journals.asm.org/doi/10.1128/mbio.01257-25
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https://journals.asm.org/doi/10.1128/mbio.01257-25

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