TNS4 promotes lymph node metastasis of gastric cancer by interacting with integrin Β1 and inducing the activation of fibroblastic reticular cell

TNS4 promotes lymph node metastasis of gastric cancer by interacting with integrin Β1 and inducing the activation of fibroblastic reticular cell

Abstract Lymph node (LN) metastasis of gastric cancer (GC) is one of the important pathways of GC metastasis, indicating the clinical staging and prognosis of patients. To investigate the underlying mechanism during the process of GC-induced LN metastasis, 7 pairs of GC tissues, paracancerous (PC) t...

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Main Authors: Xiang Zhang, Guang-Hong Su, Tian-Shang Bao, Wei-Pai He, Yang-Yang Wang, Yao-Qi Zhou, Jia-Xuan Xie, Fei Wang, Rui Lu, Shan Zhang, Shuang-Qin Yi, Qing Li, Shu-Heng Jiang, Hui Li, Li-Peng P. Hu, Jun Li, Jia Xu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer Cell International
Subjects:
Gastric cancer
Lymph node metastasis
Fibroblastic reticular cells
Tensin 4
Integrin beta 1
Online Access:https://doi.org/10.1186/s12935-025-03830-x
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https://doi.org/10.1186/s12935-025-03830-x

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