A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE)

A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE)

Abstract The adverse outcome pathway (AOP) framework serves as a practical tool for organising scientific knowledge that can be used to infer cause–effect relationships between stressor events and toxicity outcomes in intact organisms. However, a major challenge in the broader application of the AOP...

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Bibliographic Details
Main Authors: European Food Safety Authority (EFSA), Kevin M. Crofton, Martin Paparella, Anna Price, Iris Mangas, Laura Martino, Andrea Terron, Antonio Hernández‐Jerez
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:EFSA Journal
Subjects:
adverse outcome pathway
developmental neurotoxicity
developmental neurotoxicity in vitro battery
DNT
pyrethroids
systematic literature review
Online Access:https://doi.org/10.2903/j.efsa.2024.8954
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https://doi.org/10.2903/j.efsa.2024.8954

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