Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis

Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis

The incidence of Poorly cohesive carcinoma (PCC) has steadily risen in recent years, posing a significant clinical challenge. To reveal the anti-tumor effects of Jianpi Yangzheng Xiaozheng granule (JPYZXZ) in PCC, an initial investigation was performed using CCK-8, colony formation, scratch, and tra...

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Bibliographic Details
Main Authors: Xiangyang Wang, Jingxiao Li, Rong Qin, Yi Yin, Jiepin Li, Sitian Lin, Xi Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
traditional Chinese medicine
poorly cohesive carcinoma
ferroptosis
lipid metabolism
network pharmacology
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1523494/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1523494/full

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