Identification of TAPBPL as a novel negative regulator of T‐cell function

Identification of TAPBPL as a novel negative regulator of T‐cell function

Abstract T cell stimulatory and inhibitory molecules are critical for the regulation of immune responses. In this study, we identify a novel T cell co‐inhibitory molecule TAPBPL, whose amino acid sequence shares homology with known B7 family members. TAPBPL protein is expressed on resting and activa...

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Bibliographic Details
Main Authors: Yujun Lin, Cheng Cui, Min Su, Lawrence K Silbart, Haiyan Liu, Jin Zhao, Lang He, Yuanmao Huang, Dexin Xu, Xiaodan Wei, Qian Du, Laijun Lai
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:EMBO Molecular Medicine
Subjects:
autoimmune disease
B7 family
T cells
TAPBPL
tumor immunity
Online Access:https://doi.org/10.15252/emmm.202013404
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https://doi.org/10.15252/emmm.202013404

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