Hypoxia and HIF-1 inhibition enhance lentiviral transduction efficiency: a novel strategy for gene delivery optimization

Hypoxia and HIF-1 inhibition enhance lentiviral transduction efficiency: a novel strategy for gene delivery optimization

Abstract Lentiviral vectors are widely used for stable gene delivery, but their transduction efficiency can be limited by suboptimal experimental conditions. Here, we investigated the role of oxygen concentration and hypoxia-inducible factor 1 (HIF-1) signaling in lentiviral packaging and transducti...

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Bibliographic Details
Main Authors: Qianyu Huo, Wentian Wang, Jiawen Dai, Xu Yuan, Dandan Yu, Bingqi Xu, Ying Chi, Huiyuan Li, Xiao Lei Pei, Guoqing Zhu, Lei Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Biotechnology
Subjects:
Lentiviral transduction
Gene delivery optimization
Oxygen tension
Hypoxia
HIF-1 inhibitor
Transduction efficiency
Online Access:https://doi.org/10.1186/s12896-025-00969-3
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https://doi.org/10.1186/s12896-025-00969-3

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