Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain Tissue

Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain Tissue

A proviral reservoir persists within the central nervous system (CNS) of people with HIV, but its characteristics remain poorly understood. Research has primarily focused on cerebrospinal fluid (CSF), as acquiring brain tissue is challenging. We examined size, cellular tropism, and infection-dynamic...

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Main Authors: Marieke M. Nühn, Stephanie B. H. Gumbs, Pauline J. Schipper, Irene Drosou, Lavina Gharu, Ninée V. E. J. Buchholtz, Gijsje J. L. J. Snijders, Frederieke A. J. Gigase, Annemarie M. J. Wensing, Jori Symons, Lot D. de Witte, Monique Nijhuis
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Viruses
Subjects:
HIV
brain
CNS
replication-competent
cellular tropism
microglia
Online Access:https://www.mdpi.com/1999-4915/17/4/467
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