HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice

HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice

Abstract Background HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1 (HACE1) has been found to be associated with mitochondrial protection. Mitochondrial damage is a critical contributor to myocardial ischemia–reperfusion injury (I/RI). However, little is known about the role...

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Main Authors: Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cardiovascular Disorders
Subjects:
HACE1
Ischemia/reperfusion
Drp1
Mitochondrial fission
Apoptosis
Online Access:https://doi.org/10.1186/s12872-024-04445-2
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https://doi.org/10.1186/s12872-024-04445-2

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