Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway
Malignant melanoma (MM) exhibits clinical traits of vigorous metastasis and an unfavorable prognosis. Traditional therapeutic modalities such as surgical resection, radiotherapy, and chemotherapy have restricted efficacy and notable side effects, thereby urgently demanding new drugs or treatment app...
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Elsevier
2025-09-01
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| Series: | Journal of Science: Advanced Materials and Devices |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217925001108 |
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| author | Kong Jiahui Zhang Yongqiang Yang Yuchang Wang Ziheng Jing Xiaohong Lin Shuting Chen Hongyue Dong Xiaoxv Qu Changhai Cai Mengru Ni Jian Yin Xingbin |
| author_facet | Kong Jiahui Zhang Yongqiang Yang Yuchang Wang Ziheng Jing Xiaohong Lin Shuting Chen Hongyue Dong Xiaoxv Qu Changhai Cai Mengru Ni Jian Yin Xingbin |
| author_sort | Kong Jiahui |
| collection | DOAJ |
| description | Malignant melanoma (MM) exhibits clinical traits of vigorous metastasis and an unfavorable prognosis. Traditional therapeutic modalities such as surgical resection, radiotherapy, and chemotherapy have restricted efficacy and notable side effects, thereby urgently demanding new drugs or treatment approaches. The iron-doped zeolite imidazole ester skeleton material (Fe-ZIF-8, FZ) exhibits outstanding biological safety and acid-responsive drug release properties, serving as an excellent nano-delivery carrier. Oridonin (Ori) is capable of inducing ferroptosis in tumor cells by targeting key genes (such as GPX4, SLC7A11, GGT1), and demonstrates a potent therapeutic effect on MM. Simultaneously, small interfering RNA (siRNA) can exert a role in gene silencing. In this study, we devised biomimetic nanoparticles (NPs) based on iron-doped zeolitic imidazolate framework-8 (FZ) for the co-delivery of Ori and siRNA targeting GPX4 (siRNAGPX4). FZ was employed to co-load Ori and siRNA targeting GPX4, the core regulator of ferroptosis, to play a role in drug and gene therapy for MM. The A375 tumor cell membrane was biomimetically modified to construct anti-tumor drug targeted delivery nanoparticles, thereby achieving efficient co-delivery of Ori and siRNAGPX4. This provides a novel idea for the development of highly efficient and low-toxicity treatment of MM and the overcoming of tumor drug resistance. |
| format | Article |
| id | doaj-art-c33624ff35fc4b31a331a6b81b02dc5a |
| institution | Kabale University |
| issn | 2468-2179 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj-art-c33624ff35fc4b31a331a6b81b02dc5a2025-08-20T03:59:22ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792025-09-0110310095710.1016/j.jsamd.2025.100957Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathwayKong Jiahui0Zhang Yongqiang1Yang Yuchang2Wang Ziheng3Jing Xiaohong4Lin Shuting5Chen Hongyue6Dong Xiaoxv7Qu Changhai8Cai Mengru9Ni Jian10Yin Xingbin11School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, ChinaInstitute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Corresponding author.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China; Corresponding author.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China; Corresponding author.Malignant melanoma (MM) exhibits clinical traits of vigorous metastasis and an unfavorable prognosis. Traditional therapeutic modalities such as surgical resection, radiotherapy, and chemotherapy have restricted efficacy and notable side effects, thereby urgently demanding new drugs or treatment approaches. The iron-doped zeolite imidazole ester skeleton material (Fe-ZIF-8, FZ) exhibits outstanding biological safety and acid-responsive drug release properties, serving as an excellent nano-delivery carrier. Oridonin (Ori) is capable of inducing ferroptosis in tumor cells by targeting key genes (such as GPX4, SLC7A11, GGT1), and demonstrates a potent therapeutic effect on MM. Simultaneously, small interfering RNA (siRNA) can exert a role in gene silencing. In this study, we devised biomimetic nanoparticles (NPs) based on iron-doped zeolitic imidazolate framework-8 (FZ) for the co-delivery of Ori and siRNA targeting GPX4 (siRNAGPX4). FZ was employed to co-load Ori and siRNA targeting GPX4, the core regulator of ferroptosis, to play a role in drug and gene therapy for MM. The A375 tumor cell membrane was biomimetically modified to construct anti-tumor drug targeted delivery nanoparticles, thereby achieving efficient co-delivery of Ori and siRNAGPX4. This provides a novel idea for the development of highly efficient and low-toxicity treatment of MM and the overcoming of tumor drug resistance.http://www.sciencedirect.com/science/article/pii/S2468217925001108Small interfering RNAOridoninMetal-organic frameworksTumor-targeted drug delivery systemBiomimetic modification of cell membrane |
| spellingShingle | Kong Jiahui Zhang Yongqiang Yang Yuchang Wang Ziheng Jing Xiaohong Lin Shuting Chen Hongyue Dong Xiaoxv Qu Changhai Cai Mengru Ni Jian Yin Xingbin Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway Journal of Science: Advanced Materials and Devices Small interfering RNA Oridonin Metal-organic frameworks Tumor-targeted drug delivery system Biomimetic modification of cell membrane |
| title | Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway |
| title_full | Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway |
| title_fullStr | Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway |
| title_full_unstemmed | Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway |
| title_short | Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway |
| title_sort | biomimetic mofs nanoparticles co delivering oridonin and sirna for synergistic therapy in melanoma via ferroptosis pathway |
| topic | Small interfering RNA Oridonin Metal-organic frameworks Tumor-targeted drug delivery system Biomimetic modification of cell membrane |
| url | http://www.sciencedirect.com/science/article/pii/S2468217925001108 |
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