Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway

Biomimetic MOFs nanoparticles Co-delivering oridonin and siRNA for synergistic therapy in melanoma via ferroptosis pathway

Malignant melanoma (MM) exhibits clinical traits of vigorous metastasis and an unfavorable prognosis. Traditional therapeutic modalities such as surgical resection, radiotherapy, and chemotherapy have restricted efficacy and notable side effects, thereby urgently demanding new drugs or treatment app...

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Bibliographic Details
Main Authors: Kong Jiahui, Zhang Yongqiang, Yang Yuchang, Wang Ziheng, Jing Xiaohong, Lin Shuting, Chen Hongyue, Dong Xiaoxv, Qu Changhai, Cai Mengru, Ni Jian, Yin Xingbin
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Science: Advanced Materials and Devices
Subjects:
Small interfering RNA
Oridonin
Metal-organic frameworks
Tumor-targeted drug delivery system
Biomimetic modification of cell membrane
Online Access:http://www.sciencedirect.com/science/article/pii/S2468217925001108
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