Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola.

A structural rationale for recent emergence of azole (imidazole and triazole) resistance associated with CYP51 mutations in the wheat pathogen Mycosphaerella graminicola is presented, attained by homology modelling of the wild type protein and 13 variant proteins. The novel molecular models of M. gr...

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Bibliographic Details
Main Authors: Jonathan G L Mullins, Josie E Parker, Hans J Cools, Roberto C Togawa, John A Lucas, Bart A Fraaije, Diane E Kelly, Steven L Kelly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0020973
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