CHK1 inhibition overcomes gemcitabine resistance in non-small cell lung cancer cell A549

The purpose of the study is mainly to investigate anti proliferation of non-small cell lung cancer A549 cells and its mechanism by inhibition of CHK1 expression combined with gemcitabine. The mRNA and protein levels of genes were analyzed by RT-qPCR and Western blot, respectively. Cell viability was...

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Bibliographic Details
Main Authors: Zhi-Yin Ke, Tian Fu, Xue-Chun Wang, Xuan Ma, Hai-Han Yin, Wen-Xuan Wang, Yong-Jun Liu, Ai-Ling Liang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Molecular & Cellular Oncology
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Online Access:https://www.tandfonline.com/doi/10.1080/23723556.2025.2488537
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