Identification and external validation of tumor DNA methylation panel for the recurrence risk stratification of stage II colon cancer

Identification and external validation of tumor DNA methylation panel for the recurrence risk stratification of stage II colon cancer

Background: Tailoring surveillance and treatment strategies for stage II colon cancer (CC) after curative surgery remains challenging, and personalized approaches are lacking. We aimed to identify a gene methylation panel capable of stratifying high-risk stage II CC patients for recurrence beyond tr...

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Main Authors: Tanwei Yuan, Dominic Edelmann, Víctor Moreno, Elisabeth Georgii, Lisa Barros de Andrade e Sousa, Helena Pelin, Xiaofeng Jiang, Jakob Nikolas Kather, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Bläker, Hermann Brenner, Michael Hoffmeister
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Translational Oncology
Subjects:
Colon cancer
DNA methylation panel
Recurrence risk
Prognostic index
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001366
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