Development of a Recombinase-Mediated Cassette Exchange System for Gene Knockout and Expression of Non-Native Gene Sequences in <i>Rickettsia</i>

Development of a Recombinase-Mediated Cassette Exchange System for Gene Knockout and Expression of Non-Native Gene Sequences in <i>Rickettsia</i>

Background/Objectives: Incidence of vector-borne diseases, including rickettsioses and anaplasmosis, has been increasing in many parts of the world. The obligate intracellular nature of rickettsial pathogens has hindered the development of robust genetic tools for the study of gene function and the...

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Bibliographic Details
Main Authors: Benjamin Cull, Nicole Y. Burkhardt, Benedict S. Khoo, Jonathan D. Oliver, Xin-Ru Wang, Lisa D. Price, Kamil Khanipov, Rong Fang, Ulrike G. Munderloh
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
<i>Rickettsia</i>
<i>Anaplasma</i>
live-attenuated vaccine
transposon mutagenesis
genetic tools
Online Access:https://www.mdpi.com/2076-393X/13/2/109
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