Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer?
Aim. Gastrectomy with lymph node dissection is standard treatment in gastric cancer. This study aimed to explore whether preoperative investigation finds could predict lymph node metastatic scope in gastric carcinoma so that the optimal surgical procedure could be selected. Materials and Methods. Ra...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/4914201 |
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| author | Jia-Le Zhang Zhen-Ning Wang Hui-Mian Xu Zhi Zhu Bao-Jun Huang |
| author_facet | Jia-Le Zhang Zhen-Ning Wang Hui-Mian Xu Zhi Zhu Bao-Jun Huang |
| author_sort | Jia-Le Zhang |
| collection | DOAJ |
| description | Aim. Gastrectomy with lymph node dissection is standard treatment in gastric cancer. This study aimed to explore whether preoperative investigation finds could predict lymph node metastatic scope in gastric carcinoma so that the optimal surgical procedure could be selected. Materials and Methods. Radical gastrectomy patients (n=378) were separated into two groups according to the lymph node metastatic scope. Univariate and multivariate analyses of preoperative examination results were performed to identify the predictors of metastatic scope. ROC curves were constructed, and the area under the curve (AUC) was calculated to estimate diagnostic values. Results. Serum CEA (OR: 3.73; 95% CI: 1.84–7.56; P≤0.001), tumor size (OR: 2.07; 95% CI: 1.08–3.98; P=0.03), and CT examination results (OR: 17.81; 95% CI: 9.18–34.55; P≤0.001) were identified as independent predictors. The AUC proved that they possessed significant diagnostic value. When CT examination was negative, the combination of serum CEA and tumor size showed high specificity (95.3%; 164/172), negative predictive value (92.7%; 164/177), and accuracy (89.0%; 170/191). Conclusions. Preoperative serum CEA, tumor size, and CT examination are independent predictors of lymph node metastatic scope and can be used for selecting the appropriate lymphadenectomy pattern in gastric cancer patients. |
| format | Article |
| id | doaj-art-c2e86bec1f65442d88cc2e327b43e29d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-c2e86bec1f65442d88cc2e327b43e29d2025-02-03T05:45:22ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/49142014914201Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer?Jia-Le Zhang0Zhen-Ning Wang1Hui-Mian Xu2Zhi Zhu3Bao-Jun Huang4Department of Surgical Oncology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Surgical Oncology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Surgical Oncology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Surgical Oncology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, ChinaDepartment of Surgical Oncology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, ChinaAim. Gastrectomy with lymph node dissection is standard treatment in gastric cancer. This study aimed to explore whether preoperative investigation finds could predict lymph node metastatic scope in gastric carcinoma so that the optimal surgical procedure could be selected. Materials and Methods. Radical gastrectomy patients (n=378) were separated into two groups according to the lymph node metastatic scope. Univariate and multivariate analyses of preoperative examination results were performed to identify the predictors of metastatic scope. ROC curves were constructed, and the area under the curve (AUC) was calculated to estimate diagnostic values. Results. Serum CEA (OR: 3.73; 95% CI: 1.84–7.56; P≤0.001), tumor size (OR: 2.07; 95% CI: 1.08–3.98; P=0.03), and CT examination results (OR: 17.81; 95% CI: 9.18–34.55; P≤0.001) were identified as independent predictors. The AUC proved that they possessed significant diagnostic value. When CT examination was negative, the combination of serum CEA and tumor size showed high specificity (95.3%; 164/172), negative predictive value (92.7%; 164/177), and accuracy (89.0%; 170/191). Conclusions. Preoperative serum CEA, tumor size, and CT examination are independent predictors of lymph node metastatic scope and can be used for selecting the appropriate lymphadenectomy pattern in gastric cancer patients.http://dx.doi.org/10.1155/2018/4914201 |
| spellingShingle | Jia-Le Zhang Zhen-Ning Wang Hui-Mian Xu Zhi Zhu Bao-Jun Huang Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer? Gastroenterology Research and Practice |
| title | Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer? |
| title_full | Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer? |
| title_fullStr | Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer? |
| title_full_unstemmed | Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer? |
| title_short | Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer? |
| title_sort | can preoperative examination help choose the best surgical procedure in gastric cancer |
| url | http://dx.doi.org/10.1155/2018/4914201 |
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