Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways

Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways

Abstract Background Atherosclerosis (AS), a chronic inflammatory disease of the arterial wall, remains a dominant cause of death and disability globally. Quercetin has been evidenced to be effective against AS, but the exact mechanisms are still largely unclear. Methods Oxidized low-density lipoprot...

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Bibliographic Details
Main Authors: Xiao Liang, Jingyuan Zhang, Jiangbo Yu, Jiyi Zhao, Shusen Yang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:European Journal of Medical Research
Subjects:
Quercetin
Atherosclerosis
Cellular senescence
Aortic endothelial cells
Macrophages
Autophagy
Online Access:https://doi.org/10.1186/s40001-025-02562-y
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https://doi.org/10.1186/s40001-025-02562-y

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