Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD

Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD

Abstract Background The role of eosinophils in COPD and their utility as biomarkers for cytokine targeting monoclonal therapies remains unclear. We investigated the distribution of eosinophils across different tissue compartments in COPD and analysed gene expression to understand the possible mechan...

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Main Authors: Karl J. Staples, Jodie Ackland, Sruthymol Lukose, Bastian Angermann, Graham Belfield, Maria Belvisi, Raghothama Chaerkady, Damla Etal, Ashley Heinson, Sonja Hess, Ventzislava A. Hristova, Michael Hühn, Christopher McCrae, Daniel Muthas, Lisa Öberg, Kristoffer Ostridge, Adam Platt, C. Mirella Spalluto, Alastair Watson, Tom Wilkinson, the MICAII study group
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Respiratory Research
Subjects:
COPD
Exacerbations
Eosinophils
Online Access:https://doi.org/10.1186/s12931-025-03177-x
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https://doi.org/10.1186/s12931-025-03177-x

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