Small extracellular vesicles enhance the survival of Sca-1+ cardiac stem cells against ROS-induced ischemic-reoxygenation injury in vitro

Small extracellular vesicles enhance the survival of Sca-1+ cardiac stem cells against ROS-induced ischemic-reoxygenation injury in vitro

Abstract Background Ischemic reperfusion (IR) generates reactive oxygen species (ROS) that inevitably result in myocardial cell death and heart failure. The regenerative power of cardiac progenitor/stem pools (CSCs), especially the Sca1+ population, in response to IR injury remains unclear. Methods...

Full description

Saved in:
Bibliographic Details
Main Authors: Radwa A. Mehanna, Hagar Elkafrawy, Marwa M. Essawy, Samar S. Ibrahim, Ashraf K. Awaad, Nehal A. Khalil, Marwa A. Kholief, Abeer Sallam, Heba A. Hamed, Mona A. Barkat, Mohamed F. ElKady, Eman H. Thabet
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biological Research
Subjects:
BMMSCs-derived small extracellular vesicles
Cardiac stem cells
Ischemia-reperfusion injury
miRNA-21-5p
PTEN/pAkt/HIF-1α pathway
Online Access:https://doi.org/10.1186/s40659-025-00593-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s40659-025-00593-7

Similar Items