The DJ-1-Binding Compound Exerts a Protective Effect in Both In Vitro and In Vivo Models of Sepsis-Induced Acute Kidney Injury

The DJ-1-Binding Compound Exerts a Protective Effect in Both In Vitro and In Vivo Models of Sepsis-Induced Acute Kidney Injury

Although sepsis-induced acute kidney injury (AKI) is associated with significant morbidity and mortality, its treatment remains unresolved. Oxidative stress and inflammation are key elements in the pathomechanism of AKI. Therefore, in the present study, we investigated the role of DJ-1 protein, know...

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Main Authors: Réka Zrufkó, Csenge Pajtók, Beáta Szebeni, Apor Veres-Székely, Mária Bernáth, Csenge Szász, Péter Bokrossy, Attila J. Szabó, Ádám Vannay, Domonkos Pap
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antioxidants
Subjects:
DJ-1
PARK7
sepsis
acute kidney injury
oxidative stress
inflammation
Online Access:https://www.mdpi.com/2076-3921/14/6/719
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https://www.mdpi.com/2076-3921/14/6/719

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