NFATc1 deficiency in B cells ameliorates atopic dermatitis

NFATc1 deficiency in B cells ameliorates atopic dermatitis

Abstract Atopic dermatitis (AD) is a common skin allergy, affecting large population worldwide. Currently, there is no cure for AD. NFATc1, a transcription factor, operates through a calcium-dependent calcineurin/calmodulin pathway to regulate target genes and is vital in immune system development a...

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Main Authors: Hidaya Abdul Kader, Syed Sabih Ur Rehman, Dhanya Saraswathiamma, Sadiya Sadiq Shiek, Antonio A. Bencomo-Hernández, Ubaid Rahman Moorakkan, Muhammad Touseef Haider, Nayla Munawar, Rabah Iratni, Edgar Serfling, Mohammad Tauqeer Alam, Khalid Muhammad
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Atopic dermatitis (AD)
Regulatory B cells (Bregs)
IL-10
NFATc1
IgE
Online Access:https://doi.org/10.1038/s41598-025-11247-9
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https://doi.org/10.1038/s41598-025-11247-9

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