Frequency of synaptic antigen-specific CD4+ T cells in dementia is age-dependent but not correlated with cognitive impairment

Frequency of synaptic antigen-specific CD4+ T cells in dementia is age-dependent but not correlated with cognitive impairment

Abstract Neurodegenerative dementias including Alzheimer disease severely impair cognitive and social abilities and are a major cause of mortality with no causal treatment yet. Autoimmune mechanisms have been increasingly considered to contribute to disease progression, e.g. by enhancing protein mis...

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Main Authors: Julius Hoffmann, Marie-Luise Machule, Jakob Kreye, Laura Stöffler, Péter Körtvelyessy, Maria Buthut, Rosa Rößling, Petra Bacher, Alexander Scheffold, Harald Prüss
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Immunity & Ageing
Subjects:
Synaptic autoantigens
Immune senescence
T cells
Dementia
NMDA receptor
LGI1
Online Access:https://doi.org/10.1186/s12979-025-00516-w
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https://doi.org/10.1186/s12979-025-00516-w

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