Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia

Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia

Background Liver X receptors (LXRs) are expressed in placenta and may be associated with pre-eclampsia (PE). Oxysterols act as agonists for LXRs. We recently proposed a new blood pressure-regulating circuit with oxysterol 4β-hydroxycholesterol (4βHC) acting as a hypotensive factor via LXRs.Materials...

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Main Authors: Lassi Kaartinen, Tiina Jääskeläinen, Eeva Sliz, Gamze Yazgeldi Gunaydin, Satu Wedenoja, Shintaro Katayama, Eero Kajantie, Valtteri Rinne, Seppo Heinonen, Juha Kere, Heta Merikallio, Hannele Laivuori, Janne Hukkanen
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Annals of Medicine
Subjects:
Liver X receptor
pre-eclampsia
4β-hydroxycholesterol
placenta
oxysterol
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2025.2495763
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https://www.tandfonline.com/doi/10.1080/07853890.2025.2495763

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