CRISPR/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production

CRISPR/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production

Abstract Rotaviruses pose a significant threat to young children. To identify novel pro- and anti-rotavirus host factors, we performed genome-wide CRISPR/Cas9 screens using rhesus rotavirus and African green monkey cells. Genetic deletion of either SERPINB1 or TMEM236, the top two antiviral factors,...

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Main Authors: Yinxing Zhu, Meagan E. Sullender, Danielle E. Campbell, Leran Wang, Sanghyun Lee, Takahiro Kawagishi, Gaopeng Hou, Alen Dizdarevic, Philippe H. Jais, Megan T. Baldridge, Siyuan Ding
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-01007-7
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https://doi.org/10.1038/s41541-024-01007-7

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