Recombinant vectors based on porcine adeno-associated viral serotypes transduce the murine and pig retina.

Recombinant vectors based on porcine adeno-associated viral serotypes transduce the murine and pig retina.

Recombinant adeno-associated viral (AAV) vectors are known to safely and efficiently transduce the retina. Among the various AAV serotypes available, AAV2/5 and 2/8 are the most effective for gene transfer to photoreceptors (PR), which are the most relevant targets for gene therapy of inherited reti...

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Main Authors: Agostina Puppo, Alexander Bello, Anna Manfredi, Giulia Cesi, Elena Marrocco, Michele Della Corte, Settimio Rossi, Massimo Giunti, Maria Laura Bacci, Francesca Simonelli, Enrico Maria Surace, Gary P Kobinger, Alberto Auricchio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059025&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059025&type=printable

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