Morinda officinalis oligosaccharides attenuate mitochondria-associated ferroptosis via the NOX4/mitoGPX4 pathway in myocardial ischemia‒reperfusion injury

Morinda officinalis oligosaccharides attenuate mitochondria-associated ferroptosis via the NOX4/mitoGPX4 pathway in myocardial ischemia‒reperfusion injury

AimTo explore the benefits of Morinda officinalis oligosaccharides (MOO) on ischemia-reperfusion (I/R) injury and the possible mechanisms involved.MethodsMyocardial I/R injury were induced by left anterior descending branch ligation. MOO pretreatment was given orally 2 weeks prior to ischemic treatm...

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Main Authors: Yuqiong Chen, Yuan Tian, Bo Guan, Yiling Chang, Xiaopei Yan, Qi Song, Wenting Chen, Lin Chen, Wei Li, Wenjun Mao, Yan Zhang, Chao Chen, Su Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Morinda officinalis oligosaccharides
myocardial ischemia-reperfusion injury
NOX4
GPx4
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1605513/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1605513/full

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