Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18

Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18

Background Interleukin-18 (IL-18), or interferon (IFN)-γ-inducing factor, potentiates T helper 1 and natural killer cell activation as well as CD8+ T-cell proliferation. Recombinant IL-18 has displayed limited clinical efficacy in part due to the expression of the decoy receptor, IL-18 binding prote...

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Bibliographic Details
Main Authors: Yu Liu, Yichi Zhang, Yayi Hou, Yan Cheng, Mengyu Zhang, Yuanhui Zhao, Dongge Xu, Weikang Sun, Yuqing Miao, Susu He, Dwayne Stupack, Erguang Li
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/12/e009716.full
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