USP19 deficiency enhances T-cell-mediated antitumor immunity by promoting PD-L1 degradation in colorectal cancer

USP19 deficiency enhances T-cell-mediated antitumor immunity by promoting PD-L1 degradation in colorectal cancer

Colorectal cancer (CRC) is characterized by a highly immunosuppressive tumor microenvironment, which limits the effectiveness of current immunotherapies. Identifying strategies to overcome this resistance is critical for improving treatment outcomes. In this study, we discovered that USP19 plays a p...

Full description

Saved in:
Bibliographic Details
Main Authors: Feng Shi, Guang-Jing Li, Yi Liu, Hai-Meng Zhou, Yue Zhang, Si-Yi Wei, Bo-Jun Zan, Meng Gao, Fei-Shan Chen, Bo-Xin Li, Bai-Qi Wang, Ming-You Dong, Run-Lei Du, Xiao-Dong Zhang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Pharmacological Research
Subjects:
Colorectal cancer
Ubiquitin-specific protease 19
Programmed death-ligand 1
Tumor immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000933
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S1043661825000933

Similar Items