6-mercaptopurine Metabolites as Predictors of Neutropenia and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia

6-mercaptopurine Metabolites as Predictors of Neutropenia and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia

Background: 6-Mercaptopurine (6-MP) is used to treat childhood acute lymphoblastic leukemia (ALL). The concentrations of 6-MP metabolites in red blood cells (RBCs), specifically 6-thioguanine (6-TG) and 6-methyl mercaptopurine nucleotides (6-MMP), are associated with the drug’s therapeutic responses...

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Bibliographic Details
Main Authors: Ebrahim Salehifar, Omid Abed Khojasteh, Seyed Jalal Hosseinimehr, Hossein Karami, Mohammad Naderi Sorki, Hadi Darvish-Khezri, Kimia Karami
Format: Article
Language:English
Published: Mazandaran University of Medical Sciences 2025-01-01
Series:Journal of Pediatrics Review
Subjects:
acute lymphoblastic leukemia (all)
6- mercaptopurine (6-mp)
neutropenia
hepatotoxicity
Online Access:http://jpr.mazums.ac.ir/article-1-683-en.pdf
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http://jpr.mazums.ac.ir/article-1-683-en.pdf

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