Synthesis and Cytotoxic Activity of Conjugates of Mitochondrial-Directed Cationic Compound F16 with Ursane-Structure Triterpenic Acids Containing a Polyhydroxylated A-ring

Synthesis and Cytotoxic Activity of Conjugates of Mitochondrial-Directed Cationic Compound F16 with Ursane-Structure Triterpenic Acids Containing a Polyhydroxylated A-ring

We chemically linked corosolic and asiatic acids and a synthetic polyoxygenated analogue of ursolic acid via an alkyl linker to the cationic mitochondrial targeting compound F16 (4-(1H-indole-3-ylvinyl)-<i>N</i>-methylpyridinium iodide). The conjugates were tested for cytotoxic activity...

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Bibliographic Details
Main Authors: Anna Spivak, Darya Nedopekina, Eldar Davletshin
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Chemistry Proceedings
Subjects:
ursolic acid
conjugates
polyhydroxylated A-ring
delocalized lypophilic cations
F16
anti-cancer agents
Online Access:https://www.mdpi.com/2673-4583/14/1/43
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