Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep

<b>Aim:</b> In this study, it was aimed to determine the effect of IM marbofloxacin at different doses on biochemical and hematological parameters in healthy sheep.<p> <b>Materials and Methods:</b> The study was carried out on twenty four healthy Akkaraman rams (2-5 yea...

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Main Authors: Feray Altan, Orhan Çorum, Duygu Durna Çorum, Kamil Üney
Format: Article
Language:English
Published: Selcuk University Press
Series:Eurasian Journal of Veterinary Sciences
Subjects:
Online Access:http://eurasianjvetsci.org/pdf.php3?id=1202
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author Feray Altan
Orhan Çorum
Duygu Durna Çorum
Kamil Üney
author_facet Feray Altan
Orhan Çorum
Duygu Durna Çorum
Kamil Üney
author_sort Feray Altan
collection DOAJ
description <b>Aim:</b> In this study, it was aimed to determine the effect of IM marbofloxacin at different doses on biochemical and hematological parameters in healthy sheep.<p> <b>Materials and Methods:</b> The study was carried out on twenty four healthy Akkaraman rams (2-5 years old) randomly selected in four dose groups according to parallel design. There are six animals in each dose group. There are six animals in each dose group. Six animals in each group were injected with marbofloxacin at the dose levels of 2, 4, 6 and 10 mg/kg, respectively, in the semitendinosus muscle. Blood samples were collected using a catheter placed in the left jugular vein at 0 (pre-treatment), and 10. and 22 hours post-dosing. Biochemical parameters, such as, albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, triglyceride, total protein, blood urea nitrogen, creatinine, and gamma-glutamyl transferase were determined in autoanalyzer. Hematological parameters, such as white blood cells, red blood cells, hemoglobin, hematocrit, and platelet were measured in blood cell counter.<p> <b>Results:</b> No significant differences in hematological and serum biochemical parameters were found between the groups.<p> <b>Conclusion:</b> These results indicate that the marbofloxacin after a single intramuscular injection up to 10 mg/kg following IM administration in sheep had no significant side effects on the biochemical and hematological parameters measured.
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language English
publisher Selcuk University Press
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series Eurasian Journal of Veterinary Sciences
spelling doaj-art-c22ebfead3c94c01af5ee72b15d59ed42025-02-03T11:25:39ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-195334271761202Effects of different doses marbofloxacin on biochemical and hematological parameters in sheepFeray Altan0Orhan Çorum1Duygu Durna Çorum2Kamil Üney3Dicle Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Diyarbakır, TürkiyeKastamonu Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Kastamonu, TürkiyeKastamonu Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Kastamonu, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, 42031, Türkiye<b>Aim:</b> In this study, it was aimed to determine the effect of IM marbofloxacin at different doses on biochemical and hematological parameters in healthy sheep.<p> <b>Materials and Methods:</b> The study was carried out on twenty four healthy Akkaraman rams (2-5 years old) randomly selected in four dose groups according to parallel design. There are six animals in each dose group. There are six animals in each dose group. Six animals in each group were injected with marbofloxacin at the dose levels of 2, 4, 6 and 10 mg/kg, respectively, in the semitendinosus muscle. Blood samples were collected using a catheter placed in the left jugular vein at 0 (pre-treatment), and 10. and 22 hours post-dosing. Biochemical parameters, such as, albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, triglyceride, total protein, blood urea nitrogen, creatinine, and gamma-glutamyl transferase were determined in autoanalyzer. Hematological parameters, such as white blood cells, red blood cells, hemoglobin, hematocrit, and platelet were measured in blood cell counter.<p> <b>Results:</b> No significant differences in hematological and serum biochemical parameters were found between the groups.<p> <b>Conclusion:</b> These results indicate that the marbofloxacin after a single intramuscular injection up to 10 mg/kg following IM administration in sheep had no significant side effects on the biochemical and hematological parameters measured.http://eurasianjvetsci.org/pdf.php3?id=1202biochemicalhaematolojicalmarbofloxacinsheepside effect
spellingShingle Feray Altan
Orhan Çorum
Duygu Durna Çorum
Kamil Üney
Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
Eurasian Journal of Veterinary Sciences
biochemical
haematolojical
marbofloxacin
sheep
side effect
title Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
title_full Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
title_fullStr Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
title_full_unstemmed Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
title_short Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
title_sort effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
topic biochemical
haematolojical
marbofloxacin
sheep
side effect
url http://eurasianjvetsci.org/pdf.php3?id=1202
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