Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep
<b>Aim:</b> In this study, it was aimed to determine the effect of IM marbofloxacin at different doses on biochemical and hematological parameters in healthy sheep.<p> <b>Materials and Methods:</b> The study was carried out on twenty four healthy Akkaraman rams (2-5 yea...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1202 |
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| author | Feray Altan Orhan Çorum Duygu Durna Çorum Kamil Üney |
| author_facet | Feray Altan Orhan Çorum Duygu Durna Çorum Kamil Üney |
| author_sort | Feray Altan |
| collection | DOAJ |
| description | <b>Aim:</b> In this study, it was aimed to determine the effect of IM
marbofloxacin at different doses on biochemical and hematological
parameters in healthy sheep.<p>
<b>Materials and Methods:</b> The study was carried out on twenty
four healthy Akkaraman rams (2-5 years old) randomly selected
in four dose groups according to parallel design. There are six
animals in each dose group. There are six animals in each dose
group. Six animals in each group were injected with marbofloxacin
at the dose levels of 2, 4, 6 and 10 mg/kg, respectively, in
the semitendinosus muscle. Blood samples were collected using
a catheter placed in the left jugular vein at 0 (pre-treatment),
and 10. and 22 hours post-dosing. Biochemical parameters,
such as, albumin, alkaline phosphatase, alanine aminotransferase,
aspartate aminotransferase, cholesterol, triglyceride, total
protein, blood urea nitrogen, creatinine, and gamma-glutamyl
transferase were determined in autoanalyzer. Hematological
parameters, such as white blood cells, red blood cells, hemoglobin,
hematocrit, and platelet were measured in blood cell counter.<p>
<b>Results:</b> No significant differences in hematological and serum
biochemical parameters were found between the groups.<p>
<b>Conclusion:</b> These results indicate that the marbofloxacin after
a single intramuscular injection up to 10 mg/kg following IM
administration in sheep had no significant side effects on the
biochemical and hematological parameters measured. |
| format | Article |
| id | doaj-art-c22ebfead3c94c01af5ee72b15d59ed4 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-c22ebfead3c94c01af5ee72b15d59ed42025-02-03T11:25:39ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-195334271761202Effects of different doses marbofloxacin on biochemical and hematological parameters in sheepFeray Altan0Orhan Çorum1Duygu Durna Çorum2Kamil Üney3Dicle Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Diyarbakır, TürkiyeKastamonu Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Kastamonu, TürkiyeKastamonu Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Kastamonu, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, 42031, Türkiye<b>Aim:</b> In this study, it was aimed to determine the effect of IM marbofloxacin at different doses on biochemical and hematological parameters in healthy sheep.<p> <b>Materials and Methods:</b> The study was carried out on twenty four healthy Akkaraman rams (2-5 years old) randomly selected in four dose groups according to parallel design. There are six animals in each dose group. There are six animals in each dose group. Six animals in each group were injected with marbofloxacin at the dose levels of 2, 4, 6 and 10 mg/kg, respectively, in the semitendinosus muscle. Blood samples were collected using a catheter placed in the left jugular vein at 0 (pre-treatment), and 10. and 22 hours post-dosing. Biochemical parameters, such as, albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, triglyceride, total protein, blood urea nitrogen, creatinine, and gamma-glutamyl transferase were determined in autoanalyzer. Hematological parameters, such as white blood cells, red blood cells, hemoglobin, hematocrit, and platelet were measured in blood cell counter.<p> <b>Results:</b> No significant differences in hematological and serum biochemical parameters were found between the groups.<p> <b>Conclusion:</b> These results indicate that the marbofloxacin after a single intramuscular injection up to 10 mg/kg following IM administration in sheep had no significant side effects on the biochemical and hematological parameters measured.http://eurasianjvetsci.org/pdf.php3?id=1202biochemicalhaematolojicalmarbofloxacinsheepside effect |
| spellingShingle | Feray Altan Orhan Çorum Duygu Durna Çorum Kamil Üney Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep Eurasian Journal of Veterinary Sciences biochemical haematolojical marbofloxacin sheep side effect |
| title | Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep |
| title_full | Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep |
| title_fullStr | Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep |
| title_full_unstemmed | Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep |
| title_short | Effects of different doses marbofloxacin on biochemical and hematological parameters in sheep |
| title_sort | effects of different doses marbofloxacin on biochemical and hematological parameters in sheep |
| topic | biochemical haematolojical marbofloxacin sheep side effect |
| url | http://eurasianjvetsci.org/pdf.php3?id=1202 |
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