African swine fever virus MGF505-3R facilitates ferroptosis to restrict TBK1-IRF3 pathway

African swine fever virus MGF505-3R facilitates ferroptosis to restrict TBK1-IRF3 pathway

ABSTRACT African swine fever virus (ASFV) causes hemorrhagic, severe infectious diseases and serious economic losses to the pig industry. ASFV multigene family 505 can antagonize the host’s innate immunity through multiple signaling pathways and is considered an important target for vaccine developm...

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Main Authors: Sai Niu, Ying Zhou, Chunyue Fang, Yonggen Yang, Junjie Wang, Shandian Gao, Hanchuan Dai
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
African swine fever virus
MGF505-3R
GPX4
ferroptosis
IRF3
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03423-24
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https://journals.asm.org/doi/10.1128/spectrum.03423-24

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