Ganoapplanilactone C from <i>Ganoderma applanatum</i> Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish

Ganoapplanilactone C from <i>Ganoderma applanatum</i> Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish

A phytochemical study of <i>Ganoderma applanatum</i> identified four predominant triterpenoids, with ganoapplanilactone C (GATC) exhibiting the most significant lipid-reducing effects in high-fat diet-fed zebrafish, surpassing atorvastatin at 5 μM. Histopathological analysis confirmed GA...

Full description

Saved in:
Bibliographic Details
Main Authors: Yifan Guo, Mengke Zhang, Jiayang Xu, Mengyue Dong, Xin Chen, Anan Yang, Jinming Gao, Xia Yin
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antioxidants
Subjects:
<i>Ganoderma applanatum</i>
bioactive compounds
MASLD
metabolomics
AMPK/mTOR pathway
Online Access:https://www.mdpi.com/2076-3921/14/6/637
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2076-3921/14/6/637

Similar Items