hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer

hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer

Abstract Ovarian cancer has the highest mortality rate among gynecologic tumors worldwide, with unclear underlying mechanisms of pathogenesis. RNA-binding proteins (RBPs) primarily direct post-transcriptional regulation through modulating RNA metabolism. Recent evidence demonstrates that RBPs are al...

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Main Authors: Fengjiang Qin, Yuya Wang, Chenyue Yang, Yifei Ren, Qinglv Wei, Yan Tang, Jie Xu, Haocheng Wang, Fatao Luo, Qingya Luo, Xin Luo, Xiaoyi Liu, Dan Yang, Xinzhao Zuo, Yu Yang, Chunming Cheng, Jing Xu, Wei Wang, Tao Liu, Ping Yi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60115-7
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https://doi.org/10.1038/s41467-025-60115-7

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