A novel solid phase synthesis of an estradiol derivative and preclinical evaluation for targeting estrogen-receptor positive breast cancer

A novel solid phase synthesis of an estradiol derivative and preclinical evaluation for targeting estrogen-receptor positive breast cancer

Abstract [18F]-Fluoroestradiol, which is recently approved by the FDA, is a well-recognized estrogen receptor radiopharmaceutical in nuclear medicine to investigate both primary and metastatic breast cancers. This study introduces an innovative and effective method for synthesizing the DOTA-coupled...

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Bibliographic Details
Main Author: Subhani M. Okarvi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Estradiol
Estrogen receptor
Breast cancer
Radiotheranostic
Tumor targeting.
Online Access:https://doi.org/10.1038/s41598-025-15367-0
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https://doi.org/10.1038/s41598-025-15367-0

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