41 Elucidating the altered metabolism of NAD+ in the selective targeting of glioblastoma with the NQO1- activated drug β-lapachone
Objectives/Goals: NAD+ synthesis is enhanced in glioblastoma (GBM) allowing GBM to resist chemotherapy. NQO1 is upregulated in GBM and may be targeted by β-lapachone (β-lap) to induce NAD-depletion and cell death. This project investigates NQO1 as a selective target for GBM and the contributions of...
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2025-04-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866124007283/type/journal_article |
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