African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis

African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis

Abstract The African swine fever virus (ASFV) has been reported to cause oxidative damage and inhibit IFN-β production. However, the precise mechanisms through which ASFV-induced lipid peroxidation modulates the innate immune response remain to be elucidated. Here, we investigated the regulatory mec...

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Bibliographic Details
Main Authors: Yiqin Chen, Junjie Wang, Ying Zhou, Mingze Liu, Wenjie Li, Yian Deng, Yonggen Yang, Chunyue Fang, Sai Niu, Jinxia Dai, Hanchuan Dai
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
ASFV A151R
cGAS-STING pathway
Lipid peroxidation
Ferroptosis
Innate immunity
Online Access:https://doi.org/10.1007/s00018-025-05732-7
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https://doi.org/10.1007/s00018-025-05732-7

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