Deficiency of IL-7R attenuates abdominal aortic aneurysms in mice by inhibiting macrophage polarization towards M1 phenotype through the NF-κB pathway

Deficiency of IL-7R attenuates abdominal aortic aneurysms in mice by inhibiting macrophage polarization towards M1 phenotype through the NF-κB pathway

Abstract Background Abdominal aortic aneurysm (AAA) is a common degenerative disease of the abdominal aorta, which can result in extremely high mortality owing to the rupture of the abdominal aorta. The activation of IL-7R has been shown to modulate the inflammatory responses, which play an importan...

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Bibliographic Details
Main Authors: Shengnan Xu, Xueyu Han, Yi Yu, Chuan Qu, Bo Yang, Bo Shen, Xin Liu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Medicine
Subjects:
Abdominal aortic aneurysm
Macrophages
M1 macrophage polarization
IL-7/IL-7R
NF-κB pathway
Online Access:https://doi.org/10.1186/s10020-025-01209-2
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https://doi.org/10.1186/s10020-025-01209-2

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