Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics

Background: Selective serotonin reuptake inhibitors (SSRIs) are a first-line pharmacological therapy in major depressive disorder (MDD), but treatment response rates are low. Clinical trials lack the power to study the genetic contribution to SSRI response. Real-world evidence from electronic health...

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Main Authors: Chris Wai Hang Lo, Alexandra C. Gillett, Matthew H. Iveson, Michelle Kamp, Chiara Fabbri, Win Lee Edwin Wong, Dale Handley, Oliver Pain, Evangelos Vassos, Naomi R. Wray, Heather C. Whalley, Danyang Li, Allan H. Young, Andrew M. McIntosh, Cathryn M. Lewis
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Biological Psychiatry Global Open Science
Subjects:
Antidepressant response
Electronic health records
Generation Scotland
GWAS
Selective serotonin reuptake inhibitors (SSRIs)
UK Biobank
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174325000564
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