SUMO2 inhibits ACSL3 protein degradation to antagonize erastin-induced ferroptosis in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is the prevalent form of primary liver cancer with a high rate of morbidity and death. Ferroptosis is a kind of regulatory cell death mode that depends on iron. Small ubiquitin-like modifier 2 (SUMO2) is linked to HCC progression; however, its role in ferropto...

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Bibliographic Details
Main Authors: Yanxi Shen, Bin Ye, Chuanfei Li
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
Online Access:https://doi.org/10.1007/s12672-025-02921-5
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