Ensemblex: an accuracy-weighted ensemble genetic demultiplexing framework for population-scale scRNAseq sample pooling

Ensemblex: an accuracy-weighted ensemble genetic demultiplexing framework for population-scale scRNAseq sample pooling

Abstract Multiplexing samples from distinct individuals prior to sequencing is a promising step towards achieving population-scale single-cell RNA sequencing by reducing the restrictive costs of the technology. Individual genetic demultiplexing tools resolve the donor-of-origin identity of pooled ce...

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Main Authors: Michael R. Fiorini, Saeid Amiri, Allison A. Dilliott, Cristine M. Yde Ohki, Lukasz Smigielski, Susanne Walitza, Edward A. Fon, Edna Grünblatt, Rhalena A. Thomas, Sali M. K. Farhan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Subjects:
Single-cell RNA sequencing
Multiplexing
Sample pooling
Genetic demultiplexing
Induced pluripotent stem cells
Differential gene expression
Online Access:https://doi.org/10.1186/s13059-025-03643-1
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https://doi.org/10.1186/s13059-025-03643-1

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