Genetically modified macrophages accelerate myelin repair

Genetically modified macrophages accelerate myelin repair

Abstract Preventing neurodegeneration‐associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in patients might enhance neuroprotection. In demyelinating mouse lesions, local o...

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Main Authors: Marie‐Stéphane Aigrot, Clara Barthelemy, Sarah Moyon, Gaelle Dufayet‐Chaffaud, Leire Izagirre‐Urizar, Beatrix Gillet‐Legrand, Satoru Tada, Laura Bayón‐Cordero, Juan‐Carlos Chara, Carlos Matute, Nathalie Cartier, Catherine Lubetzki, Vanja Tepavčević
Format: Article
Language:English
Published: Springer Nature 2022-07-01
Series:EMBO Molecular Medicine
Subjects:
gene therapy
multiple sclerosis
oligodendrocyte progenitor cells
remyelination
semaphorin 3F
Online Access:https://doi.org/10.15252/emmm.202114759
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https://doi.org/10.15252/emmm.202114759

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